Vitamin K2 MK-4 Research

El Asmar MS, Naoum JJ, Arbid EJ. Vitamin K Dependent
Proteins and the Role of Vitamin K2 in the Modulation
of Vascular Calcification: A Review.  Oman Med J 2014
May 29;(3):172-177.  LEARN MORE

Shiraki M, Shiraki Y, Aoki C, Miura M. Vitamin K2
(Menatetrenone) Effectively Prevents Fractures and
Sustains Lumbar Bone Density in Osteoporosis.
J Bone Miner Res. (2000) 15:515-521.  LEARN MORE

Miki T, Nakatsuka K, Naka H, Kitatani K, Saito S, Masaki H,
Tomiyoshi Y, Morii H, Nishizawa Y. Vitamin K2 (menaquinone-4)
Reduces Serum Undercarboxylated Osteocalcin Level as Early
as 2 Weeks in Elderly Women with Established Osteoporosis.

J Bone Miner Metab (2003) 21:161-165.  LEARN MORE

Okamoto H, Shidara K, Hoshi D, Kamatani N. Anti-Arthritis
Effects of Vitamin K2 (menaquinone-4) – A New Potential
Therapeutic Strategy for Rheumatoid Arthritis.

FEBS J 274 (2007) 4588-4594.  LEARN MORE

Ferland G. Vitamin K and the Nervous System: An Overview
of its Actions.
American Society for Nutrition. Adv. Nutr. 3:
204–212, 2012; doi:10.3945/an.111.001784.
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Viegas CSB., Costa RM, Santos L, Videira PA, Silva Z, Araujo N,
Macedo AL, Matos AP, Vermeer C, Simes DC. Gla-Rich
Protein Function as an Anti-Inflammatory Agent in
Monocytes/Macrophages: Implications for Calcification-
Related Chronic Inflammatory Diseases.
Published: May 18,
2017. 
https://dio.org/10.1371/journal.pone.0177829.  LEARN MORE

Viegas CSB, Cavaco S. Neves PL, Ferreira A, Joao A, Williamson
MK, et al. Gla-Rich Protein (GRP) is a Novel Vitamin K Dependent
Protein Present in Serum and Accumulated at Sites of Pathological
Calcifications.
Am J Pathol. 2009;175:2288-2298.pmid:19893032.  LEARN MORE

Viegas CSB, Herfs M, Rafael MS, Enriquez JL, Teixeira A, Luis I, et al.
Gla-Rich Protein is a Potential New Vitamin K Target
in Cancer: Evidences for a Direct GRP-Mineral Interaction.

Biomed Res Int. 2014.  LEARN MORE

Viegas CSB, Rafael M, Enriquez JL, Teixeira A, Vitorino R, Luis M, et al.
Gla-Rich Protein (GRP) Acts as a Calcification Inhibitor in the
Human Cardiovascular System.
Arterioscler Thromb Vasc Biol.
2015;35:399-408.pmid:25538207.  
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Viegas CS and Simes DC. New Perspectives for the Nutritional
Value of Vitamin K in Human Health.
J Nutr Disorders Ther.
2016;6:3.  
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